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Assisted hopping and interaction effects in impurity models
L. Borda,F. Guinea
Physics , 2004, DOI: 10.1103/PhysRevB.70.125118
Abstract: We study, using Numerical Renormalization Group methods, the generalization of the Anderson impurity model where the hopping depends on the filling of the impurity. We show that the model, for sufficiently large values of the assisted hopping term, shows a regime where local pairing correlations are enhanced. These correlations involve pairs fluctuating between on site and nearest neighbor positions.
Expresión tisular de proteínas reparadoras e infiltración linfocítica tumoral: significado pronóstico en el carcinoma colorrectal resecado Tissular expression of mismatch repair proteins and tumour lymphocytic infiltration: prognostic significance in resected colorectal carcinoma
F. Borda,J.M. Martínez-Pe？uela,A. Borda,J. Urman
Anales del Sistema Sanitario de Navarra , 2012,
Abstract: Fundamento. En el cáncer colorrectal se discute la posible relación entre la expresión patológica de proteínas reparadoras (EPPR) y la infiltración linfocítica tumoral (ILT), así como el posible efecto pronóstico de ambos factores. Material y métodos. Se han revisado 243 cánceres colorrectales, resecados consecutivamente. Estudiamos inmunohistoquímicamente la EPPR de MLH1, MSH2 y MSH6. La ITL se valoró mediante la tinción de CD3 en el epitelio tumoral. Comparamos la mortalidad y progresión tumoral post-operatoria entre los casos con y sin EPPR y con y sin ITL. Adicionalmente estudiamos la mortalidad y progresión tumoral entre los casos EPPR (+), según presentaran o no ITL. Resultados. El 13,6% tumores expresaron EPPR (+) y el 25,5% ITL (+). El seguimiento fue: 73,8±34,6 meses. La frecuencia de ITL (+) resultó similar entre tumores EPPR (+): 27,3% y EPPR (-): 25,2% (p = 0,80). Los casos EPPR (+) mostraron menor mortalidad: 12,1% versus 23,3% (p = 0,15) y menor progresión tumoral: 21,2% versus 29% (p = 0,35). Las neoplasias ITL (+) tuvieron menor mortalidad: 9,7% versus 26% [p = 0,007; OR = 3,27(1,25-9,05) ] y progresión tumoral: 12,9% versus 33,1% [p = 0,002; OR = 3,35 (1,42-8,15) ]. Los 9 tumores EPPR (+) e ILT (+) no presentaron mortalidad ni progresión tumoral, frente a una mortalidad: 16,7% y progresión: 29,2% de los 24 casos EPPR (+) e ITL (-) p = 0,19 y p = 0,07 respectivamente. Conclusiones. No se ha encontrado relación entre EPPR e ITL, con tasas muy similares de ILT (+) entre casos con y sin EPPR. La ILT (+) mostró un efecto pronóstico favorable superior a la EPPR (+). La combinación de ILT (+) e EPPR (+) parece tener un efecto protector acumulativo, aunque su escasa frecuencia resta significación al hallazgo. Background. In colorectal cancer there is discussion about the possible relation between the mismatch repair protein expression (MMRPE) and tumour lymphocytic infiltration (TLI), as well as the possible prognostic effect of both factors. Methods. A review was made of 243 colorectal cancers, consecutively resected. We made an immunohystochemical study of the MMRPE of MLH1, MSH2 and MSH6. The TLI was evaluated through CD3 staining in the tumoural epithelium. We compared mortality and post-operative tumoural progression amongst the cases with and without MMRPE and with and without TLI. Additionally, we studied mortality and tumoural progression amongst MMRPE (+) cases, according to whether or not they presented TLI. Results. Thirteen point six percent of the tumours expressed MMRPE (+) and 25.5% TLI (+). The follow-up was: 73.8±34.6 months. Th
Papel de la ecoendoscopia en el estudio etiológico de la pancreatitis aguda idiopática
Vila,J. J.; Borda,F.; Jiménez,F. J.;
Revista Espa？ola de Enfermedades Digestivas , 2008, DOI: 10.4321/S1130-01082008000200006
Abstract: up to 30% of patients with acute pancreatitis are diagnosed of idiopathic acute pancreatitis after an initial evaluation including a complete clinical history, physical examination, analysis with calcium and triglycerides determination, and at least one transabdominal ultrasonography. unexplained pancreatitis represents a diagnostic challenge, although after different explorations a cause is found in the majority of these patients. during the last years endosonography has proved to be a low morbidity exploration very useful in the evaluation of patients with this entity. in this article we review the role of endosonography in the etiologic study of patients with idiopathic acute pancreatitis.
Papel de la ecoendoscopia en el estudio etiológico de la pancreatitis aguda idiopática The role of endoscopic ultrasonography in the etiological evaluation of idiopathic acute pancreatitis
J. J. Vila,F. Borda,F. J. Jiménez
Revista Espa？ola de Enfermedades Digestivas , 2008,
Abstract: Hasta el 30% de los pacientes con pancreatitis aguda son diagnosticados de una pancreatitis aguda idiopática tras un estudio inicial que debe incluir una anamnesis completa, exploración física, análisis con determinación de calcio y triglicéridos y al menos una ecografía abdominal. Esta situación representa un reto diagnóstico, aunque en la mayoría de los casos se encuentra una causa que justifique la pancreatitis tras realizar diferentes exploraciones diagnósticas. En los últimos a os la ecoendoscopia está demostrando ser de gran utilidad en el estudio de estos pacientes, produciendo a cambio una baja morbilidad. En este artículo hacemos una revisión del papel de la ecoendoscopia en el estudio etiológico de la pancreatitis aguda idiopática. Up to 30% of patients with acute pancreatitis are diagnosed of idiopathic acute pancreatitis after an initial evaluation including a complete clinical history, physical examination, analysis with calcium and triglycerides determination, and at least one transabdominal ultrasonography. Unexplained pancreatitis represents a diagnostic challenge, although after different explorations a cause is found in the majority of these patients. During the last years endosonography has proved to be a low morbidity exploration very useful in the evaluation of patients with this entity. In this article we review the role of endosonography in the etiologic study of patients with idiopathic acute pancreatitis.
Phase diagram of the dissipative quantum particle in a box
J. Sabio,L. Borda,F. Guinea,F. Sols
Physics , 2007, DOI: 10.1103/PhysRevB.78.085439
Abstract: We analyze the phase diagram of a quantum particle confined to a finite chain, subject to a dissipative environment described by an Ohmic spectral function. Analytical and numerical techniques are employed to explore both the perturbative and non-perturbative regime of the model. For small dissipation the coupling to the environment leads to a narrowing of the density distribution, and to a displacement towards the center of the array of accessible sites. For large values of the dissipation, we find a phase transition to a doubly degenerate phase which reflects the formation of an inhomogeneous effective potential within the array.
Differential β1 Cardiac Adrenoceptor Modulation of Nitric Oxide Isoforms by β1 IgG from Patients with Periodontitis during Short-Term Hypoxia  [PDF]
Sabrina Ganzinelli, Enri Borda
Pharmacology & Pharmacy (PP) , 2015, DOI: 10.4236/pp.2015.612057
Abstract: Background: We demonstrated previously that serum IgG from periodontitis patients interacting with the second extracellular loop of the human cardiac β1 adrenoreceptors triggers the production of second messengers. In this paper we quantified the production of nitrates/nitrites and nitric oxide (NO), which in turn induces nitric oxide synthase (NOS) mRNA expression. Methods: We determined using β1 IgG, NOS activity isoforms, NOS expression, nitrate/nitrite assay, cGMP accumulation and PKC activity. Results: We established that serum β1 IgG autoantibodies and NO might be considered as early markers in normoxia/hypoxia system in rat isolated atria. The β1 IgG autoantibodies from periodontitis patients, while stimulating myocardial atria β1 adrenoreceptors, exert an increase on NO levels indirectly quantified as nitrite/nitrate, which acts as NO-storage molecules with significant increase in neuronal NOS (nNOS) and inducible NOS (iNOS) mRNA levels in hypoxia conditions. The significant increase in nNOS/iNOS mRNA and NOS activity as well as in NO levels after short-time hypoxia in rat isolated atria was detected. The expression of these genes are related with the increase in atria dF/dt, cyclic GMP (cGMP) and protein kinase C (PKC) activity and resemble the results obtained by Isoproterenol, an β1 adrenoreceptor agonist. Conclusion: These findings indicate that short-term hypoxia up-regulated rat atria NO/NOS system in the presence of β1 IgG autoantibodies shows that an antibody interacting with rat atria β1 adrenoreceptor can act as expression inducer of proinflammatory NO and its metabolites and that it might be useful and helps to maintain heart function and to prevent necrosis and subsequent loss of heart function during hypoxia.
Biomphalaria tenagophila potencial vector of Schistosoma mansoni in the Paraná River basin (Argentina and Paraguay)
Borda, C Edgardo;Rea, María Josefa F;
Memórias do Instituto Oswaldo Cruz , 2007, DOI: 10.1590/S0074-02762007005000022
Abstract: susceptibility and compatibility experiments were carried out with 700 biomphalaria tenagophila from the paraná river basin exposed to infection with schistosoma mansoni. individual infection was performed with 10 miracidia of sj2 strain from the paraiba valley (brazil) originally infective to b. tenagophila. these snails were laboratory-breed progeny of b. tenagophila collected from six localities of argentina and one from paraguay. from argentina: rincón de vences (7%) and posadas (11%) became infected with s. mansoni and the calculation of frandsen's index (tcp/100) shows that they were class ii poorly compatible. those snails from goya (22%), maloyas (5%), and berón de astrada (3%) were class iii compatible to the s. mansoni. none of the 100 snails exposed from caá-catí became infected (class 0 incompatible). tested samples from paraguay (encarnación) were infected (20%) and compatible (class iii). it was also studied the persistence of the infection in 244 snails of the first generation (f1) of those that were susceptible from three places. it was demonstrated an increment of the susceptibility in the f1 from maloyas (c2 = 27.22; p = 0.0001) and posadas (c2 = 4.24; p = 0.04). the results point out the possibility that schistosomiasis might be able to spread into the paraná river basin where b. tenagophila exists.
Susceptibility and compatibility of Biomphalaria tenagophila from the Río de la Plata basin with Schistosoma mansoni from Brazil
Borda, Carlos Edgardo;Rea, María Josefa F;
Memórias do Instituto Oswaldo Cruz , 2010, DOI: 10.1590/S0074-02762010000400025
Abstract: schistosomiasis has expanded to southern parts of brazil. between 2005-2007 the dispersion and the proliferation of biomphalaria tenagophila was verified in the province of corrientes near the brazilian border. in order to study the possibility that schistosomiasis might spread into the basins of the paraná and uruguay rivers, 440 b. tenagophila collected from 10 populations groups were experimentally exposed to infection with schistosoma mansoni of the sj2 strain. snails from five localities were susceptible. frandsen's index (tcp/100) shows that those snails from mirungá (11%), aguacerito (2%) and curupicay (2%) were class i and not very compatible. meanwhile, snails from copra (6%) and pay-ubre (22%), in the paraná river basin, were class ii and poorly compatible.
Tiene utilidad el tratamiento preoperatorio con ácido ursodeoxicólico en la reducción de las recidivas en la pancreatitis aguda biliar? Is pre-operative treatment with ursodeoxycholic acid useful in reducing relapses in acute biliary pancreatitis?
F. Borda,S. Oqui？ena,E. Borobio,J. Vila
Anales del Sistema Sanitario de Navarra , 2003,
Abstract: En el presente trabajo se ha valorado la posible reducción de la tasa de recidivas en la pancreatitis aguda biliar mediante el tratamiento con ácido ursodeoxicólico (AUC) entre el episodio de pancreatitis y el momento de la colecistectomía. Se estudiaron 72 primeros episodios consecutivos de pancreatitis aguda biliar, en pacientes no colecistectomizados, seguidos hasta la cirugía. Los casos se dividieron en grupo A (n = 30), tratados al alta con AUC 10 mg/kg/día, hasta la cirugía, y grupo B o control (n = 42). Se evaluaron las diferencias entre ambos grupos en cuanto a características del paciente, gravedad de la pancreatitis, características de la litiasis y demora hasta la cirugía. Analizamos las recidivas de la pancreatitis entre los grupos con y sin AUC. En el grupo con AUC comparamos la duración del tratamiento entre los pacientes con y sin recidiva de la pancreatitis. Los dos grupos no mostraron diferencias significativas en cuanto a ninguno de los parámetros estudiados. Registramos 7/30 (23,3%) recidivas en el grupo AUC, frente a 9/42 (21,4%) recidivas en el control (p = 0,85). Dentro del grupo AUC, la duración del tratamiento fue similar entre los casos que recidivaron: 4,9±4,5 meses y los no recidivados: 4,4±1,9 meses (p = 0,78). En nuestra experiencia, el empleo de AUC hasta el momento de la colecistectomía no reduce la incidencia de recidiva en los pacientes tras un primer episodio de pancreatitis aguda biliar. La duración del tratamiento con AUC tampoco parece relacionarse con la aparición o no de recidivas. In the present paper, we evaluate the possible reduction in the rate of relapses in acute biliary pancreatitis through treatment with ursodeoxycholic acid (UCA), between the episode of pancreatitis and the moment of cholecystectomy. We studied 72 consecutive first episodes of acute biliary pancreatitis, in patients who had not yet undergone colecistectomy, followed up until surgery. The cases were divided into group A (n=30), treated with ursodeoxycholic acid 10 mg/kg/day, until surgery, and group B or control (n=42). We evaluated the differences between both groups, regarding patient characteristics, pancreatitis severity, characteristics of the lithiasis and delay until surgery. We analysed pancreatitis relapses in both groups, with and without UCA. In the UCA group we compared the duration of treatment between patients with and without pancreatitis relapse. The two groups did not show significant differences regarding any of the studied parameters. We registered 7/30 (23.3%) relapses in UCA group, versus 9/42 (21.4%) relapses in the c
Estudio de la frecuencia, distribución y rendimiento diagnóstico en las lesiones neoplásicas sincrónicas del carcinoma colo-rectal
Borda,A.; Martínez-Pe？uela,J.M.; Prieto,C.; Mu？oz,M.; Carretero,C.; Borda,F.;
Anales del Sistema Sanitario de Navarra , 2008, DOI: 10.4321/S1137-66272008000100004
Abstract: aim. to analyse the frequency, characteristics and diagnosis of synchronic neoplastic lesions in colorectal cancer. methods. a review was carried out of 384 colorectal cancers, diagnosed through complete colonoscopy and resected. the synchronic cancers and the characteristics of the adenomas were determined: number, size, histological type, dysplasia, as well as their localisation in the colon and with respect to the carcinoma. results. twenty-eight synchronic cancers were found (7.3% of the total); 8 developed tumours and 20 malignant polyps. in 54.4% of the cases there was a synchronic adenoma. in patients with synchronic lesions, 43% showed an advanced adenoma. twenty percent of the synchronic polyps found were proximal to the splenic flexure; 41% were distal and 38% had both localisations. fifty-nine point one percent of the patients had some adenoma proximal to the cancer, with criteria of advanced adenoma in 13.9%. the distribution of the adenomas was more uniformly spread in the cancers with a proximal localisation (p = 0.038). seventeen percent of the distal cancers presented synchronic lesions with a proximal colon localisation exclusively. partial endoscopies would diagnose the distal cancers, but would omit a synchronic adenoma in 42.3% of the sigmoidoscopies and 40% of the short colonoscopies. conclusions. high rates of carcinoma and synchronic adenomas were registered. we underline the high index of advanced adenomas and the frequency of synchronic lesions proximal to the cancer, which is why incomplete colonoscopies, although allowing the diagnosis of the distal cancer, omit a high percentage of synchronic adenomas, including advanced lesions. all of this confirms the need to perform a complete pre-, intra- and post operational colonoscopy in resectable colorectal cancer.
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